Wow, I was really surprised at the amount of responses- this really is a great support group! I went to see my doc today and he was concerned as he expected the tablets to start working after 14 days. He has recommended I take another kind so I will see how it goes. I have to stop taking the Serdep for a few days before I start the new medication and am a bit worried I might feel worse. Thanks so much for all the effort Wildcat, I really appreciate your info. My doc also suggested I go for councilling to deal with my issues that contribute to my feeling so down.