I am currently taking zoloft and want some opions. I need to take xanax once a day to cope with my anxiety and panic. Zoloft is supposed to help this where i dont need the xanax anymore. I have just upped my dose to 100mg and it makes my anxiety worse. Does anybody else have this problem with meds? Is this normal? I have tried Paxil, Cymbalta, and Lexapro all have made me feel out of it. Is there any advise. Is it possible that meds just wont work?