If it helps any, I was on that exact combination of meds until about 3 months ago. I slowly stopped the Effexor (the withdrawal is another story!) and am now on Cipralex (Lexapro in the US) and Wellbutrin instead. I'm still not completely convinced this is the right combo, but I'm giving it a try -- this is about the third or fourth med change in the last 8 years, and each one seems to be better than the last. I hope you get some help adjusting or changing the meds -- it sounds like something needs to be changed.

Hi Missing I think Melamie is defimitely right. It would be best to seek the advice of a doctor or pharmacist about medications. I wanted to respond to your poisting though as I think one or two things can be said safely, and hopefully usefully. You mentioned that you were previously seeing a psyhiatrist, but are now being prescribed these medications by your family doctor. I can't help wondering, from what you say, whether it might be better to see if you can find another psychiatrist. Even if you only saw them once or twice they would, I am sure, have greater specialist knowledge than your family doctor on your medication issues. In my country, the UK, family doctors manage the overwhelmeing majority of patients with depression, but they do refer a small percentage of people on to psychiatrists or psychologists etc. I would also say that in the UK most family doctors (we call them general practitioners) would not be too experienced in prescribing multiple antidepressants to an individual patient. They would tend to try one at a time, and if this didn't work would think about referring on. I don't, however, know what the position is where you live. "Cocktails" of medications don't seem too uncommon in those who post here, although they may of course have been initiated by a specialist and then continued by the family doctor. You also mentioned that initially the combo worked very well, but that for the last 6 months you have been "sliding downhill". Again, I feel that it would be impossible for anyone on this site to be able to say with any confidence what is happening here. If you don't mind me saying so, if you were doing very well for 2 months but then have been going downhill for the last 6 months, then I really do feel that you should ideally have been under the care of a doctor with specialist knowledge throughout the whole of that time. None of this is any of your fault, and these things can happen when doctors finish etc, but speaking strictly as a non-medical person, it would seem by far the "aafest" thing to do, if at all possible, would be to see a new psychiatrist, or related specialist, as soon as you can. In the meantime you could also speak to the pharmacy as well. They could give you some general information about these me

Missing, The Depression Center offers personalized, interactive tools that have helped thousands of people challenge and overcome their depression. At this time we our members and moderators are unable to provide you with information regarding medications and their dosages. It is best to speak with your doctor and or pharmacy. Respectfully, Melanie

I am currently on 300mg of Effexor and 150mg Wellbutrin. The first two months on this combo was great but for the last 6 months I have been sliding downhill. My doctor won't up it unless I tell him to and only then if I have a good reason. Should I ask for a higher dosage? Is it just that I am not trying hard enough to get better? Or should I be asking to switch drugs? I really need some advice as my doctor won't do anything unless I can convince him to. I know that sounds bad but it is my family doc who is now prescribing the anti depressants as my psychyatrist closed her practice 6 months ago. My family doctor is really cautious when it comes to drugs. Sometimes almost too cautious. Any advice would be great.