I've been on antidepressants, specifically Zoloft and Wellbutrin, for almost two years now. They seemed to have worked fairly well for me. While I have still struggled with depression, at least the heaviness and crying all time had improved. More recently though, due to certain stressors I have slipped back down into a deeper depression. So how does one know if the medication is still working. Although my current depression is pretty bad, it may be much worse without the medication? Or perhaps the medication isn't working as well as it used to. How does one tell which it is?