Greetings...I've been on Zoloft for about 5 years and AderalXR as well. I would really appreciate advice on a change in meds. AderalXR 20mg/day is working great/ADD, but Zoloft 300mg/day has been loosing effectiveness/Depression. My doc recommended a change to Effexor; I have been on Effexor for about 5 days, and I'm worse off than when I was on Zoloft. Is this temporary? I am a bit concerned--Prior to Zoloft, I was on Wellbutrin for about 2 weeks, and I lost COMPLETE control of myself. Currently on Effexor, I have noticed short periods of rage. Any Advice???