It's estimated that tobacco causes about one in five (the equivalent of about 443,000 ) deaths each year. Of these, around 49,000 smoking related deaths are the result of exposure to secondhand smoke.
Centers for Disease Control and Prevention. Smoking-Attributable Mortality, Years of Potential Life Lost, and Productivity Losses—United States, 2000–2004. Morbidity and Mortality Weekly Report 2008;57(45):1226–8. Retrieved Oct 22. 2011.