I'm a strong believer in both calcium and Vitamin D to help with depression. In addition to depression, I suffer from fibromyalgia so I take magnesium and tumeric to help with inflammation and brain fog. As you mentioned.... gotta check these out with your doctor to see what works for you. Everyone is different. It helped me to check in with my doc, but I know me better than anyone else and I had to do the research and go through trial and error before I found what works for me. Right now, my prescription meds are Cymbalta (for depression & fibromyalgia) and a low dose of Seroquel (for anxiety & to help sleep). ~m