I just want to give hope to people, who like me tried everything else, that they can succeed with the help of ADs. I too used to say well.. what if it doesn't work for me. It took a lot of convincing from my pdoc & gp that they WILL work, even if I have to try a few. They said that very few people do not respond to ADs, if any. I myself, hope they were right, as it is sometimes a last resort, and a depressed person NEEDS to know that something WILL work. If that makes any sense? If someone can overcome depression without meds, AMEN!! That would be the ideal, and I'm sure it happens everyday. There is just something comforting, (there was for me anyway) in knowing that if all else fails, ADs will help. Something has to.