Hi again Bob-
I don't know what those studies show. i only know about my own experiences. there have been several times in my life when i was on anti depressants and for one reason or another went off from them. now that my doctor has found the right dosage and the right combination of them, i don't think i would ever go off from them again. yes there can be side effects. when i first started taking them i had extreme nausea but it subsided after about a week. i do have dry mouth but it is a small price to pay for the benefit i get. everyone is affected differently by meds- some people don't have any side effects at all. i consider the meds i take for my depression akin to the meds my husband takes for his high blood pressure. they are what i need in order to live a healthy life. thanks for asking. Karen