My husband has said that he has started taking medication for major depression. He told me he was taking Remeron, and if he started when he said he had, it has been about six weeks. He said that it was the same medication that he was on before, and it worked. But, he doesn't seem to be any different at all. Not like he was the first time when he dealt with his first major despression. He is still very angry and cannot seem to put his family in the right perspective.